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The agreement is good news the French biotech Innate Pharma. The company, based in Marseille, in a statement anounce the signing of a global agreement with the U.S. laboratory Bristol-Myers Squibb (BMS).

BMS is thus committed to finance the development of the IPH2102, a new antibody in Phase I development created by the biotech Marseille for the treatment of cancer. Thus, the U.S. laboratory to make an initial payment of Innate Pharma $ 35 million, followed by other milestone payments based on research findings. The total amount of the transaction could reach $ 465 million (over 320 million euros).Innate Pharma should also receive a fee, a "double-digit percentage" of international sales net of the product.

In exchange, "Innate Pharma will provide Bristol-Myers Squibb exclusive worldwide rights to develop, manufacture and marketing of IPH2102 and compounds structurally related KIR receptor blocking."

Innate Pharma flies title

"This license agreement is the largest ever made to date with a French biotech in financial terms," ​​said Hervé Brailly, CEO of Innate Pharma. "Bristol-Myers Squibb is a global leader in the field of immuno-oncology and as the best partner we could look to realize the full potential of IPH2102," he adds.

To BMS is a new step in its strategy of "string of pearls."The giant seeks to "establish collaborations with innovative businesses and leaders in their field worldwide," said Mike Seeley, CEO of BMS France.

The announcement of the agreement was followed closely by investors. The title Innate Pharma jumped nearly 80% in early trade, to 2.35 euros. The CAC 40 rose 0.46%.

It's been five years since the U.S. housing bubble deflates, after swelling for fourteen years. The consequences of this reversal are still stopping the economy and financial system of the United States poor credit personal loans.

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Bulky Bin Hamman and Warner
Except turnaround unlikely, Sepp Blatter was re-elected for the third time as President of FIFA in Zurich Wednesday. It is not difficult to predict because the Swiss, who directs the proceedings since 1998, is the only candidate since the withdrawal this weekend in his last opponent, Qatari Mohamed bin Hammam. A forced withdrawal and the scent of scandal. President of the Asian Confederation, Ben Hamman has indeed been provisionally suspended by the Ethics Committee of FIFA because of suspicions of corruption against him. Jack Warner, CONCACAF President, Vice-President of FIFA, and support shown by Ben Hamman was also temporarily suspended for the same reasons. The two men are suspected of attempting to buy the votes of the Caribbean Confederation (CFU), which they strongly refute."I deny the allegations that I made statements to the CFU on donations from Mr. Bin Hammam," asserted Jack Warner in a statement while saying, however that "in Miami, the Congress of the Concacaf May 3, Mr Blatter had donated one million dollars to our federation, "without the consent of the finance committee of FIFA.

A gift for which an investigation had been opened before it was quickly closed by the money outright Blatter any accusation of corruption by the Ethics Commission. A past president quickly cleared and a final opponent suspended, the unfolding of events may leave pensive and may suggest that FIFA is the realm of small arrangements. Especially when the case comes just weeks after revelations of the British weekly Sunday Times about the allocation of World Cup 2022 in Qatar.Especially so when a vice-president of FIFA accredits these revelations by making public the contents of an email sent by Jerome Valcke, FIFA general secretary and confidant of Blatter. "For MBH (Editor's note: Mohamed Bin Hamman), I've never understood why he was entering the race. Or so he thought that one can buy FIFA as the Qataris have purchased the World Cup, "Valcke reportedly wrote in an email sent to Warner!

Blatter on the royal road
A blow to Blatter camp when the Swiss campaigned on a zero tolerance towards corruption Online payday loans.But Jerome Valcke has justified his writings stating that "it can happen to employ a less formal tone when I use this medium which by its nature, encourages exchanges" lighter "than other forms correspondence "and that" in referring to the FIFA World Cup 2022 in this e-mail, I wanted to highlight that the future host country had used its financial strength to rally much support (…) I n 'I at no time refers to the buying of votes or any behavior inconsistent with the rules of ethics. "Sepp Blatter, he is right in his boots remained Monday at a press conference in emergency to try to extinguish the many fires in the house FIFA.

"We must fight the demons, there's a bad situation, but there will be an elective congress on Wednesday and the family of football, if it wants to restore the credibility of FIFA, can do with me," Blatter said, refusing to evoke the decisions of the Commission on Ethics ("I'm not allowed to comment") and denying the existence of a crisis within the federation he heads ("football is not crisis when we see the final of the Champions League, he just some difficulty "). So everything is for the best in the best of worlds for Blatter whose reelection is no longer any doubt.Because on the eve of polling, it is unclear how the appeal of Bin Hamman, the request for postponement of the FA made on Tuesday or calls for reform from places like Australia (Editor's note: England and Australia respectively were candidates to host the World Cups 2018 and 2022), could prevent the Swiss to begin a fourth term. Starting what happens under the sign of the scandal …

Respect the rules of good governance at Renault while responding to questions about the French role in the company, without destabilizing it. It is the balancing act, politically dangerous and embarrassing that the state has since the collapse of the case. It may well be the largest shareholder of Renault, he is not alone in charge. If he holds 15% of the manufacturer, the state has two representatives on nineteen to the Board of Directors: Luc Rousseau, Director of the Directorate General of competitiveness and Industry at Bercy, and Alexis Kohler , Agency of State Holdings. It can not, in principle, to impose its views.

What it can do however is put the pressure. In both media and politics.When deemed necessary, it does not deprive it: Who does not remember the vitriolic statements of head of state, ignoring all rules of governance, demanding the resignation of Daniel Bouton after the affair Kerviel ?

"Everything has to be rebuilt"

Not so with the Renault affair, in which the Executive has been careful not to fan the embers. Although his handling of the crisis raises many critics, Carlos Ghosn is an internationally recognized industrial, away from the myth of "bad bank" that returned the boss of Societe Generale in full heart of the financial crisis. The CEO of Renault also plays "an important role in the Franco-Japanese alliance," said a government source, not to say that it is really unavoidable No teletrak payday loan.Finally, the company is a French industrial flagship, major employer.

The government had every reason not wanting to weaken and was careful from the beginning of the case not to attack frontally with his boss. "Our role is not to say this or that person is responsible," said Minister of Industry, Eric Besson … before adding yesterday that the audit conducted by Renault ended "to the conclusion that four people should be punished." As for the Minister of Economy Christine Lagarde said she had "instructed state officials who sit on the board, support the recommendations of the report of the audit committee."

Hiding behind the investigation that he himself requested, the state got what he wanted without seeming too intrusive. The departure would have added a number one crisis to crisis.The sacrifice the number two avoids return the image of a state shareholder leaving everything. At Bercy, where Christine Lagarde knows well the operating companies to have been in his previous life as head of law firm Baker & McKenzie in Chicago, it is noted that "the solution to the problem has been properly found, in accordance with rules of governance "and that" everything is now to rebuild. "

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The sensational espionage case that shook Renault continued on Sunday to "deflate". One of the three security officials of the automotive group into custody-to-view this weekend, Dominique Gevrey, was referred Sunday to the Paris prosecutor, while a judicial inquiry was opened for "scam organized gang ", following the dismissal last January three group executives for espionage.

Dominique was in the wake Gevrey be presented to the examining magistrate for a possible indictment. "We will communicate about it in a comprehensive and complete after the floor, probably Monday," warned counsel for Renault. Two of the three leaders in custody to view this weekend, including the director of security and close to Carlos Ghosn, Remi Pagni, however, were released Sunday morning, without any charges being brought against them.

The two frameworks safety first taken into custody-to-view, and Marc Dominique Gevrey Tixador, both authors of the report which led to the dismissal of three employees, have so far refused to reveal the name of the informant the source of accusations of espionage. By the reckoning of Renault's lawyer Wednesday to a microphone Europe, the automotive group has made "in the order of 250,000 euros" in this anonymous informant, through an intermediary agent of a private intelligence to collect data that led to three dismissals.

Renault claims a "manipulation"

Renault claims not to know either the name of that source, and have asked the two security officials, "who are only to know, to deliver his name and address to the investigators," said Renault's lawyer.This same source who gave Renault numbers of three bank accounts which was based on the automotive group to accuse the three executives have coined strategic information on the program of Renault's electric vehicles.

However, investigators of the Central Directorate of Internal Intelligence (DCRI) claimed last week they had found "no evidence of bank accounts" on behalf of these employees, nor "any evidence of espionage." As a defense, Renault now evokes the idea of ​​a "manipulation". In an interview with Le Figaro, the number two carmaker, Patrick Pelata, said that if this hypothesis was confirmed, "Renault will be attentive to repair any injustice."He also designated himself as a scapegoat, saying the group will draw all the consequences of this case until the highest level of business is to say to me ".

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After the fall of the regimes in Egypt and Tunisia, tensions rise in Bahrain, Algeria and other OPEC member countries, especially Libya, the brink of "civil war" as a son of Colonel Muammar Gaddafi in power for 42 years, which would have left the country to seek refuge in Brazil or Venezuela, according to Al Arabiya.

On oil markets, the reaction is, as always, immediately on Monday morning. In Asian trading, a barrel of light sweet crude for March delivery gained 1.13 dollars to 87.33 dollars. As for Brent North Sea crude for April delivery, it took $ 1.02 to 103.54 dollars, a threshold of novueau strong techinque. "The main factor (this flight) is the disturbed situation in the Middle East," said Victor Shum, an analyst in Singapore, saying.He said that "Libya is a member of OPEC and although its oil production is modest at the global level, the country is near the main suppliers of black gold of the planet easy to get unsecured personal loans."

Renewed uncertainty requires the price of gold, a safe haven par excellence, also increased and currently process close to $ 1400, exactly at 1395.10 euros (+1.8%), and its highest Historical. Even tedance on silver prices, which hit a record last thirty years.

FinallyThe food prices are approaching the "level of alert," warned the World Bank on the sidelines of the meeting of G20 finance ministers in Paris, which revealed that between June and December, rising food prices has dropped 44 million people worldwide below the extreme poverty.

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The CAC 40 is expected to open cautiously on Tuesday after Wall Street closed Monday without direction. Asian stock markets are also changing in a disorganized Tuesday morning.

The macroeconomic news will be a little more animated than Monday.

In France, INSEE released the first results of National Accounts Fourth quarter: French growth reached 0.3% in the fourth quarter, the low end of analysts' forecast.Over the full year 2010, GDP grew by 1.5%.

For the euro area, are provided for 11 hours, an estimate of GDP last quarter of 2010 and the European Union, and foreign trade figures in December 2010.

United States, are planned, retail sales in January, import prices in January and activity in the area of New York (1430), net long term capital in December (15 hours ) and inventories and business sales in December (16 hours).

On the currency markets, the euro rose against the dollar from 0.20% to 1.3517 dollar.

EDF: A sharp drop in earnings in 2010

On the corporate side, the publication of results is ongoing.

EDF reported a 73.9% drop in net income in 2010 to 1.02 billion euros, due to provisions related to lower energy prices.However, the group expects an increase of 4% to 6% of its EBITDA in 2011.

Air Liquide will announce Tuesday a revenue increase of over 12% for 2010, to 13.5 billion euros and net profit up 14% to $ 1.4 billion, Les Echos reported .

A merger agreement between Sanofi-Aventis and Genzyme should be signed soon, but the French laboratory should extend its offer a third time on U small personal loans.S. biotech to stop the final price of the transaction. The deadline for the offer at midnight New York time, 6 hours Wednesday Paris time.

The official announcement of the merger between Deutsche Boerse and NYSE Euronext will speak this Tuesday.A hostile bid by the Chicago Stock Exchange is in preparation, according to various U.S. media.

The Pentagon announced Monday hoped to award the next month contract to replace the aircraft-refueling tankers to the U.S. Air Force, which should put an end to a drama that has lasted nearly a decade. EADS CEO Louis Welsh reiterated that Tom Enders, Airbus president should be his successor.

Ubisoft has raised its forecast of sales for the current year after posting strong sales during the Christmas period, which is crucial for the video game industry.

Atari has announced a turnover in the first 9 months of the fiscal year 2010/2011 (April 1 to December 31, 2010) of 41.0 million euros, down 55.7% from the same period last year.

AXA Asia Pacific, a subsidiary of AXA, being acquired by IMA, said Tuesday net profit down 11% for its last fiscal year.

After market, M6 will publish its revenues and its annual results, Imerys and Euler Hermes annual results, and Mr. Bricolage and Europacorp their turnover respectively fourth and third quarters.

Speed astern for U.S. equity markets. The indices are clearly stalled after the TV overseas, including financial, broadcast live images of demonstrations in Egypt. "This aversion to risk due to escalation in Egypt, and fears that the situation could spread to other countries in the region," said Peter Cardillo, Avalon Partners.

Around 18:30, the Dow Jones lost 1.18% to 11,848.60 points, the S & P 500 1280.84 1.44% to loose points and the Nasdaq dropped 2.35% to 26,890.61 points.

As a result, oil prices leapt more than 4% in New York at 89.25 dollars

USA: disappointing growth, consumer sentiment up

On the macroeconomic front, investors first learned of the first estimate of U.S. GDP in the fourth quarter.The U.S. economy grew by 3.2% in the fourth quarter, much lower than expected, but this increase was sufficient to allow the U.S. GDP of 2.9% gain in 2010 and thus fill its losses the crisis, according to official figures published Friday.

And yet the U.S. consumer morale has improved end of January compared to the beginning of the month, hopes for improvement in terms of growth and employment eclipsing concerns about rising costs of food and gasoline, according to the confidence index released Friday by Reuters / University of Michigan. The index finally settled at 74.2 for the month of January, against an initial estimate 72.7 and 74.5 in December.Economists were expecting a index to 73.2.

On the currency side, the dollar regained ground against the euro by mid-afternoon in Paris, the single currency was trading at 1.3688 dollar.

Ford stock drops

Corporate side, the ball of results announcements of fourth quarter continues, including Chevron Corp. and Ford Motor Co and Honeywell.

Ford: -9.45% to 17.01 dollars

Ford just announced a 2010 profit more than doubled to 6.6 billion. But earnings per share fourth quarter was $ 0.05 against 0.25 a year ago due to a charge of $ 960 million related to the completion of a conversion of debt. The turnover of the 4th quarter reached $ 32.5 billion.The consensus was $ 0.48 for earnings per share and 30.39 billion dollars.

Honeywell International, 0.23% to 56.05 dollars

Honeywell International announced, meanwhile, increased its profits for the fourth quarter of 2010 and raised its forecast for 2011 due to higher demand for products produced by all its units. The industrial group posted a net profit of 369 million over the period, or $ 0 free 3-in-1 credit report.47 per share, against 150 million ($ 0.20 per share) a year ago. Honeywell raised its forecast of 10 cents earnings per share for 2011, now seen in the range 3.60 to $ 3.80.

Chevron: -0.90% to 93.90 dollars

As for Chevron, the group recorded a 81% increase in earnings in 2010 to 19.1 billion.

Amazon.com: -7.25% to 171.07 dollars

The e-commerce giant Amazon.com for its part should be very guarded on Friday, after posting yesterday after market close, the results showing strong sales but margins disappointing. All indicators are green on the year-end sales on the Internet and the action of the group posted an increase of 50% yoy and 4% on the previous day, before the publication of results that the have reduced by 9.4% in electronic trading after closing. The group announced a profit of $ 416 million, or 91 cents per share against 384 million last year. Sales are up 36% to 12.95 billion dollars. That's their strongest growth since 2000.

Microsoft: -2.39% to 28.18 dollars

Microsoft surprised everyone involved on Thursday night, unveiling its results 15 minutes before the close of Wall Street.Results marked by the success of Office 2010 and KINECTS, but disappointing sales of Windows 7. This gives the arrival of mixed results. Profits are down 5% to 6.63 billion, or 77 cents per share against 68 cents expected. Turnover was up 5% at $ 19.95 billion against $ 19.2 billion expected by analysts.

Sara Lee: -1.02% to 17.46 dollars

On the other hand, the American group of FMCG Sara Leevi clarify this Friday's market strategy, after having rejected, according to press reports, two tender offers. Sara Lee has invited investors and journalists to participate in a conference call at 15:00 Paris time.Inform the direction of its "strategic initiatives" and its outlook for the year end.

In addition, LinkedIn, the social network for professionals, announced Thursday his intention to go public in 2011, an operation that should measure the appetite of investors for a possible listing on Facebook. This is the first social network to enter the stock market and on Wall Street. But the market is expected to mainly derive an omen for Facebook, the world leader in the industry, whose value is estimated at 50 billion dollars (36.5 billion euros), and other websites may make their entry offering, or as Zynga Groupon.

A device for widespread fraud. 4000 French pharmacies are equipped with computer software allowing them to conceal part of their income in taxes. The shortfall in public finances has been estimated by one source quoted by Midi Libre, which revealed the affair, to 400 million euros. Attorney Nimes, Robert Gelli, confirmed to AFP Friday that an investigation launched in 2008 on the practice of pharmacy in the Gard Rémoulins had found the pot to the roses. "In some pharmacies and also in other activities, using software called" permissive "serve to conceal taxable transactions, and thus evade taxes," says the General Directorate of Public Finance (DGIFP).

18% of pharmacies may be affected

Two companies in France, including one based in Niort, made in France this type of software.To distort an entire accounting, only the use of a computer code would be needed and would hide on average 5000 euros of revenue each month. "The system used Remoulins not limited to the pharmacy. It is something of a national scale. 4000 pharmacies have requested access to that particular computer formula, "said Robert Gelli. France had in 2009 22.389 pharmacies, so they are nearly 18% of them who are potentially fraudeuses!

"The tax administration has launched a determined and specific action to fight against these fraudulent practices and this will be all the tax and legal consequences," reported the AFP respective department in the Ministry of Finance.And for good reason: if the latter refused to disclose the amount of damage suffered by the IRS, the 400 million raised by Midi Libre would be the same order of magnitude as the 500 million euros in revenue expected each year by the movement of the plane 10% tax loopholes.

One possible direction is to allow learning to all young people who have 15 years during a calendar year.

And how to encourage companies to take on more apprentices?

We could consider the modulation of the apprenticeship tax depending on whether businesses are close or very far from the threshold of 3% of apprentices. We could raise the quota to 5% in return when we establish a financial bonus. Finally, I think, with Christine Lagarde and Eric Besson, package some forms of public assistance (shareholding of the Strategic Investment Fund, Loan … OSEO) a commitment to "investing in human capital ' from the company – for example the recruitment of a number of apprentices.We could also do the same with the clusters, which together businesses and universities in collaborative projects supported by public funds.